A Brief Introduction: from Immune Surveillance to Tumor-immune Escape
نویسنده
چکیده
Los tumores deben evadir la respuesta inmunológica para ser clínicamente detectables en el paciente. A estos fines, las células cancerosas han desarrollado múltiples estrategias para eludir el ataque inmunológico. Estos mecanismos conspiran en estadíos avanzados de un tumor limitando la habilidad del sistema inmune para inhibir el crecimiento tumoral y la efectividad de estrategias de inmunoterapia en cáncer. Desde la biología tumoral a la clínica, en el presente artículo expondremos los más importantes mecanismos utilizados por tumores para evadir la respuesta inmunológica y su potencial impacto en el diseño de estrategias de inmunoterapia.
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تاریخ انتشار 2006